The 54 medals comprise of 23 gold, 19 silver and 12 bronze.
The medal haul is 41 clear of nearest rival Trinidad and Tobago with 13 (five gold, two silver and six bronze.
The Bahamas are in third place with 17 medals, which comprise four gold, seven silver and six bronze.
Guyana with six medals (four gold, one silver and one bronze) and Barbados with nine medals (two gold, four silver and three bronze) complete the top five.
On Saturday’s first day Jamaica took charge with 28 medals, 19 clear of second place Trinidad and Tobago.
For Jamaica, the women’s team has so far won 30 of the medal haul of 54. The 30 medals comprise 11 gold, 13 silver and six bronze.
The men’s team had won 24 medals (12 gold, six silver and six bronze).
The highlight for Jamaica on day two came from the Boys’ Under-18 x4100-metre relay team of Michali Everett, Tyreke Wilson, Xavier Nairne and Michael Stephens, who smashed the games’ record by dipping under 40 seconds to clock 39.97.
The Bahamas were well beaten into second place with a 40.77 clocking, while Trinidad and Tobago finished third in 40.84.
The Jamaican quarter lowered the previous mark of 40.40, set in 2016 by Jhevaughn Matherson, Christopher Taylor, Dejour Russell and Michael Stephens.
The blistering 39.97 clocking was faster than their Under-20 4x100-metre relay team, which won gold in 40.10.
The team, which comprises Christopher Taylor, Jelani Walker, Tyreke Bryan and Delano Dunkley, easily won the gold medal with Trinidad and Tobago finishing second for the silver medal in 40.24 seconds.
The Bahamas ended third in 40.59 seconds.
Jamaica were denied a clean sweep of the sprint relays through a disqualification as the Girls’ Under-18 4x100-metre relay team had its number taken down.
The quartet of Briana Williams, Kevona Davis, Britany Anderson and Michae Harriott won the race in a record 44.35, but the team’s glory was short-lived following the disqualification, which placed the Jamaicans out of the race.
The Girls’ Under-20 4x100-metre team of Kasheika Cameron, Aneka Brissett, Taqece Duggan and Tissanna Hickling clocked 44.83 seconds for the gold medal.
Only three teams showed up for the final with The Bahamas finishing well behind for silver in 46.45. The Turks and Caicos Islands took the bronze medal in 48.85.
Jamaica were also dominant in the 400-metre hurdles with one-two finishes in three off the four finals.
Sanique Walker set the tone by winning the Girls’ Under-18 400-metre hurdles final in a new record time of 58.95 seconds as her teammate Taffara Rose was well beaten into second with a 1:00.95 clocking.
Walker smashed the previous mark of 59.50, which was set in 2016 by Shiann Salmon, also of Jamaica.
Nicolee Foster clocked 58.84 to win the Girls’ Under-20 400-metre hurdles final as her teammate Shiann Salmon finished second in 59.59.
The other one-two finish for Jamaica came from Ronaldo Griffiths (52.01) and Timor Barrett (52.32) in the Boys’ Under-20 400-metre hurdles final.
Barbadian Rasheeme Griffith denied Jamaica a sweep of the gold medals with victory in the Boys’ Under-18 400-metre hurdles final.
Griffiths clocked 51.64 for the gold medal with Jamaican Rovane Williams finishing second in 52.69 and his teammate Dashinelle Dyer, third in 53.02.
Jamaica ended the day with three records. The other record was achieved by Daniel Cope, who won the Boys’ Under-18 shot put gold medal with a throw of 18.17 metres to erase the previous mark of 17.75 metres recorded in 2016 by Zico Campbell, also of Jamaica.
Meanwhile, Kingston College’s Carey McLeod continued his good form by handing Jamaica gold in the Boys’ Under-20 long jump with an effort of 7.62 metres.
McLeod achieved the gold medal jump with his third attempt after opening up with 7.19 metres.
The other Jamaican, Ryan Brown, finished fifth with 7.23 metres.
Jamaica also had one-two finishes in the Girls’ Under-18 discus throw final and the Boys’ Under-18 3,000-metre final.
Marie Forbes won the Girls’ Under-18 discus final with a throw of 43.62 metres, achieved on her fifth attempt, and Kimone Reid finished second with 40.39 metres.
Jamaica also secured a gold medal in the triple jump through Safin Williams ,who won the Boy’ Under-17 final with an effort of 15.11 metres.
Renardo Johnson took the Boys’ Under-18 3,000-metre final in nine minutes 30.61, just ahead of his teammate Tarees Rhoden, who clocked nine minutes 30.69.
Twenty-six coutries and territories in the region are fielding more than 600 junior athletes at the games.
Jamaica have won the games for 32 straight year and 40 times of the games’ 45-year history.
The last Jamaica lost was in 1984 when The Bahamas won at home.
Last year, Jamaica won a record 86 medals comprising 43 gold, 28 silver and 15 bronze.